In this current ‘Information Age’ humans suffer as never before, it is claimed, from the stresses of an overload of information, and the speed of global networks. The Victorians diagnosed similar problems in the nineteenth century. The medic James Crichton Browne spoke in 1860 of the ‘velocity of thought and action’ now required, and of the stresses imposed on the brain forced to process in a month more information ‘than was required of our grandfathers in the course of a lifetime’. Through this two day interdisciplinary conference, hosted by the ERC funded Diseases of Modern Life project based at Oxford, the phenomena of stress and overload, and other disorders associated with the problems of modernity in the long nineteenth century will be explored, as expressed in the literature, science, and medicine of the period. The project seeks to return to the holistic, integrative vision of the Victorians as it was expressed in the science and literature of the period, exploring the connections drawn between physiological, psychological and social health, or disease, and offering new ways of contextualising the problems of modernity facing humanity in the twenty-first century. The project is particularly interested in comparative perspectives on these issues from international viewpoints.